WEE1 and acute lymphoblastic leukemia: In ALL cell lines, AZD1775 synergized with doxorubicin to induce apoptosis associated with increased mitotic entry and deregulation of the NOTCH pathway, with minimal effects on normal progenitors (106).These data support the combination of WEE1 inhibitors with conventional chemotherapeutics for evaluation in clinical trials of relapsed or refractory ALL.