Through cascading responses such as Phosphoinositide 3-kinases/Protein kinase B (PI3K/Akt), Wingless/Integrated (Wnt), Notch, Hedgehog, and Nuclear Factor kappa B (NF-κB), it orchestrates the epithelial-mesenchymal transition (EMT), conferring migratory and invasive traits upon tumor cells (8–15). Here, NFKB1 is linked to neoplasm.