Additionally, Tlr2-/-MMTV–Wnt1 (Tlr2-/-Wnt1) mice exhibit markedly reduced tumor formation compared with that of their Tlr2+/+MMTV–Wnt1 (Tlr2+/+Wnt1) littermates, with median tumor-free days of 269 and 137, respectively (14). Here, TLR2 is linked to neoplasm.