Polysaccharide peptide (PSP) acts by upregulating the TLR4-TIRAP/MAL-MyD88 signaling pathway in peripheral blood mononuclear cells (PBMCs) from breast cancer patients, inducing the secretion of IL-12, IL-6, and TNF-α, thus serving as an immune adjuvant (90). This evidence concerns the gene TNF and breast carcinoma.