Iron regulatory proteins 1 and 2 (IRP1/2) are the main regulators of cellular iron homeostasis [117], and they play an important role in intracellular iron homeostasis under iron deficiency through the following pathways: (1) stabilize TFR1, (2) inhibit FPN1, (3) mobilize cellular iron reserves [118]. This evidence concerns the gene ACO1 and nutritional disorder.