The incidences of serious infections observed in this analysis (PsO IR 1.3, PsA IR 1.2, axSpA IR 1.1 per 100 PY) are similar to those reported in PsO, PsA, and axSpA clinical development programs of another IL-17 inhibitor [36] (PsO IR 1.4, PsA IR 1.8, axSpA IR 1.2 per 100 PY) and a TNF inhibitor [37] (PsO IR 1.8, PsA IR 2.8, axSpA IR 1.0 per 100 PY) and these are also similar to reports from real-world PsO [38], PsA [39], and axSpA populations [40]. The gene discussed is TNF; the disease is infection.