Veronica Brito et al. demonstrated that CDK5 dysfunction contributes to depressive-like behaviors in HD by altering the theDARPP-32 phosphorylation status in the Nucleus Accumbens and that CDK5 inhibition prevented depressive-like behavior and reduced DARPP-32 phosphorylation, indicating that CDK5 is a crucial factor in the development of depressive-like behaviors in HD mice [71]. This evidence concerns the gene CDK5 and Huntington disease.