HTT and Huntington disease: Using label-free quantitative mass spectrometry techniques, Karen A. Sap et al. identified proteome and ubiquitinome alterations in brain tissue of HD mouse model Q175FDN and wild-type mice, revealing differential ubiquitination of wild-type and mutant Huntingtin in both Triton X-100 soluble and insoluble fractions, and indicating that the disease affects cellular processes such as vesicular transport, gene expression, translation, catabolic processes, and oxidative phosphorylation [83].