GFAP and amyotrophic lateral sclerosis: Dong Liu et al. performed a proteomic analysis of post-mortem spinal cord tissues from individuals with and without ALS, revealing differential regulation of protein acetylation between the two groups, with GFAP being highly acetylated in ALS spinal cord and its larger fragments being upregulated in ALS spinal cord, indicating that acetylation and/or deacetylation may have a significant role in the development of ALS [91].