Scientists discovered that dysfunction of upstream binding factor-1 (UBF-1) is associated with decreased ribosomal DNA (rDNA) transcription in HD, with UBF1 acetylation at Lys (K) 352 by CREB binding protein (CBP) crucial for the transcriptional activity of rDNA, and abnormal activity of UBF1 and its acetylation by CBP linked to impaired rDNA transcription in HD, indicating that modulation of UBF-mediated rDNA synthesis by CBP could be a promising therapeutic target for enhancing neuronal rDNA transcription in HD [77]. The gene discussed is CREBBP; the disease is Huntington disease.