HTT and Huntington disease: Siah-1-interacting protein (SIP) was found by Ewelina Latoszek et al. to regulate mutated HTT aggregation in HD models, with an increase in SIP dimerization in HD medium spiny neurons causing a decrease in SIP function in the degradation of mHTT via a ubiquitin-proteasome pathway, increasing mHTT aggregation, indicating that SIP may be a potential target for anti-HD therapy during the early stage of HD pathology [80].