TARDBP and amyotrophic lateral sclerosis: Archana Prasad et al. discovered that kosmotropic anions significantly accelerate the aggregation of a C-terminal region of TDP-43 implicated in ALS, while chaotropic anions hinder it, that acetylation of specific lysines in C-terminal fragments considerably reduces the TDP-432 C’s amyloid-like aggregation, and that spontaneously formed cysteine-linked homodimers of the recombinantly purified TDP-432 C maintain amyloidogenicity [90].