PPARGC1A and Parkinson disease: Fei Fan et al. found that the nuclear translocation of PGC-1α, mediated by acetylation and phosphorylation, protects against oxidative damage in an MPP+-induced cell model of Parkinson’s disease, suggesting that therapeutic reagents activating PGC-1α may be valuable for preventing mitochondrial dysfunction in PD by mitigating oxidative damage [53].