HTT and Huntington disease: Dietary restriction (DR) rectified several effects of the transgene in the full-length YAC128 HD mouse model, such as increased body weight, reduced blood glucose, and impaired motor function, with these changes linked to decreased striatal human (but not mouse) HTT expression and changes in gene expression regulating histone acetylation modifications, particularly Hdac2, indicating a protective effect of DR in a transgenic model containing the complete human HTT gene, and for the first time suggesting a role for DR in reducing HTT level, which correlates with symptom severity [75].