MAPT and amyotrophic lateral sclerosis: Novel genetic variants in MAPT and changes in tau phosphorylation in ALS post-mortem motor cortex and cerebrospinal fluid have been identified by Tiziana Petrozziello et al., indicating the potential involvement of tau phosphorylation in ALS and proposing that cerebrospinal fluid total tau and pTau-T181 ratio could be used as biomarkers for ALS [89].