Finally, TIMER 2.0 verified that the infiltration of CD8 + T cells (Rho=-0.136, p < 0.001), B memory cells (Rho = -0.201, p < 0.001), active NK cells (Rho = -0.165, p < 0.001), and monocytes (Rho = -0.113, p < 0.001) was significantly reduced in tumor tissues, while the infiltration of NK resting cells (Rho = 0.15, p < 0.001) enhanced (Fig. 3B-C). This evidence concerns the gene CD8A and neoplasm.