It also mediates Foxo3a deacetylation and nuclear localisation, which in turn leads to the activation of Foxo3a-dependent peroxidase expression; reduces Ang II-induced renal fibrosis, endothelial-to-mesenchymal transition (EndoMT), and oxidative stress; and maintains renal endothelial homeostasis [86]. Here, FOXO3 is linked to renal fibrosis.