Sirt6 regulates renal interstitial fibrosis by deacetylating runt-related transcription factor 2 (Runx2), promotes Runx2 translocation out of the nucleus, mediates activation of the ubiquitin-protease system, causes degradation of Runx2, and inhibits vascular calcification in chronic kidney diseases (CKD) [55]. The gene discussed is SIRT6; the disease is chronic kidney disease.