Sirt6 also binds to saturated fatty acids, especially palmitic acid, promoting their nuclear export, inducing acyl-CoA synthetase long-chain 5 deacetylation, and promoting fatty acid oxidation (FAO), suggesting that Sirt6 is not restricted to the nucleus to play a metabolic regulatory role and provides a reference for its study in kidney diseases [65]. The gene discussed is SIRT6; the disease is kidney disorder.