In HER2+ and TNBC, we should first identify a pCR patient with the CS to small foci pattern or a non-pCR patient with the SD pattern; If neither, the likelihood of pCR depends on the tumor size change with OR of 1.86 in HER2+ and 1.94 in TNBC for 10% increment at 1st-timepoint, for example (Fig. 5). This evidence concerns the gene ERBB2 and neoplasm.