ERBB2 and neoplasm: In HER2+ and TNBC, the change in tumor size at 1st-timepoint (HER2+ : OR = 1.86, AUC = 0.731, both p < 0.001; TNBC: OR = 1.94, p = 0.001; AUC = 0.804, p < 0.001) had a greater impact on pCR prediction than that at 2nd-timepoint (HER2+ : OR = 1.45, p = 0.008; AUC = 0.677, p = 0.007; TNBC: OR = 1.43, p = 0.033; AUC = 0.693, p = 0.034) (Additional file 1: Table S9, Fig. S1).