Similarly, blocking the expression of histone deacetylase 2 (HDAC2), a component of PRC2, promotes histone deacetylation modifications that enhance histone stability in the nucleus, upregulating the expression of genes such as transcription factors E2F3 and TP73, thereby promoting tumor cell proliferation and inhibiting apoptosis [31, 198, 199]. The gene discussed is HDAC2; the disease is neoplasm.