Our speculation on the mechanism of action is as follows: On the one hand, TKI may act on P21 and Rb to cause more ARID1A-loss cells to enter the G1-S cell cycle arrest [190, 191]; On the other hand, some TKIs can inhibit the growth and division of cancer cells by inhibiting their angiogenesis, thereby reducing their nutrient and oxygen supply [192]. The gene discussed is ARID1A; the disease is cancer.