MSI2 and colorectal carcinoma: In addition, gene set enrichment analysis of RNA-seq data for the MSI2-high and MSI2-low groups of patients from the TCGA CRC datasets (Fig. S6A-B) and KEGG enrichment analysis of the differentially expressed genes indicated that the top-ranked upregulated pathways affected by MSI2 included the nucleocytoplasmic transport signaling pathway (Fig. 3I) and that the upregulated GO terms included regulation of intracellular protein transport, nuclear transport and nuclear export (Fig. S6C).