Remarkably, the protein expression levels of HMGB1 and acetyl-K29-HMGB1 were increased in CRC tissues with the upregulation of MSI2 (Fig. 7F), and the protein expression levels of MSI2 and HMGB1 were highly positively correlated in our clinical CRC specimens (R = 0.66, p = 1.7e-07) (Fig. 7H) and CPTAC Colon cancer dataset (R = 0.39, p = 9.7e-05) (Fig. 7J). The gene discussed is MSI2; the disease is colorectal carcinoma.