MSI2 and colitis: In addition, MSI2 knockout in type 3 (RORgt+) innate lymphoid cells in mice attenuated dextran sodium sulfate (DSS)-induced colitis pathophysiology [17], and USP10 could interact with and stabilize MSI2 through Lys48-linked deubiquitination to prevent its degradation in CRC [18], also MSI2 knockdown could trigger CRC cell ferroptosis progression [19].