Through interrogating the gene–gene interactions in the malignant cell-specific networks and cell–cell interactions between malignant cells and other cells, we identified several other genes may affect the MDK-LRP1-mediated intercellular crosstalk, such as ERBB2, ERBB3, HRAS, and ESR1. The ERBB pathway mutations have been shown to upregulate MDK expression in bladder cancer in previous studies. Here, EGFR is linked to urinary bladder cancer.