For this purpose, we proceeded to an unbiased approach by overlapping USP22-dependent transcriptomic programs identified in HCC1806 cells with several USP22 interference-based publicly available mRNA-seq datasets derived from the normal mammary epithelial cell line MCF10A, HER2+-BC models (HCC1954, MMTV-Erbb2), lung and colorectal cancer. The gene discussed is USP22; the disease is breast cancer.