USP22 and neoplasm: In addition, pharmacological inhibition of USP22 using the USP22i-S02 compound effectively abrogated the growth capacity (Fig. 3E, Fig. S1E), clonogenic potential (Fig. 3F, Fig. S1F), tumor sphere formation capacity (Fig. 3G, Fig. S1G) and migratory behavior (Fig. 3H, Fig. S2B) of TNBC cell lines.