It has been shown that ROS builds up in the gastric carcinoma cells after exposure to 5-FU activates HIF-1α-(HMGB1) signaling, which recruits M2 TAMs, which generates GDF15 (growth differentiation factor 15), and enhances fatty acid β-oxidation thus increasing the chemoresistance in them [278]. This evidence concerns the gene GDF15 and gastric carcinoma.