BCL2 and cancer: Another well-known drug is paclitaxel (PTX), which belongs to the taxane class of anticancer agents that affect the normal stability of microtubules during cell division and is effective on various cancers like breast, ovarian, etc. Although tubulin is the primary target for PTX, it has additionally been discovered to attack the mitochondria and block the activity of the apoptotic inhibitor protein Bcl-2 (B-cell Leukemia 2) [387].