Moreover in hepatocellular carcinoma (HCC), cholangiocarcinoma (CGC), and Chronic myeloid leukemia (CML) a lesser accumulation of anticancer drugs (like imatinib) seems to be mediated by a decrease in OATP1B1, OATP1B3, and OATP1A2 expression or their function [317, 320, 321]. This evidence concerns the gene SLCO1B3 and chronic myelogenous leukemia, BCR-ABL1 positive.