M2 in turn maintains CSCs features by releasing signaling molecules like CCL2, CCL5, CCL7, CCL8, CCL17, CXCL1, CXCL7, PTN, HMGB1, TGF-β, IGF, IL (10, 1β, 6, 8, 18, 35), etc. and thus support resistance and relapse of tumor [154]. The gene discussed is TGFB1; the disease is neoplasm.