PIK3CA and lobular neoplasia: Overproduction of ROS and abnormal infiltration of immune cells may be involved in lupus nephritis (LN) due to ferroptosis, as suggested by a bioinformatics study that identified eight ferroptosis-related genes (including KRAS, Mapk14, PIK3CA, EGFR, SRC, mapk3, ATM and VEG) that might be promising biomarkers of ferroptosis in LN [163].