If one or more of the symptoms or signs is present and/or the patient has an abnormal electrocardiogram, HF can be suspected, and the measurement of natriuretic peptides (NPs; BNP, B-type natriuretic peptide; NT-proBNP, N-terminal pro-B-type natriuretic peptide) is recommended. The gene discussed is NPPB; the disease is hydrops fetalis.