Other genes of potential interest commonly altered in neuroblastoma tumors included cell cycle regulators (CDK4 [5%], CDK6 [8%], and CDKN2A [16%]), chromatic remodelers (ARID1A [8%], ARID1B [11%], and SETD2 [8%]), and other genes of unknown significance (BIRC6 [11%], MDM2 [8%], RNF213 [16%], and ERBB4 [11%]). The gene discussed is MDM2; the disease is neuroblastoma.