Furthermore, Savastano A et al. found that LLPS of tau associated with Alzheimer’s disease recruited microtubulin to droplets and promoted microtubule assembly, while phosphorylation at Thr231 disrupted the binding of the proline-rich region P2 of tau to microtubulin and blocked the assembly process [39]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.