TARDBP and frontotemporal dementia: In 2020, a study showed that dimethylarginine (DMA) of poly-GR, a dipeptide repeat protein (DPR) associated with TDP-43 inclusions, in the brains of C9orf72 FTD/ALS patients reduced the strength of interactions between poly-GR molecules and decreased the phase separation of poly-GR [109].