KCNQ1OT1 and fragile X syndrome: We confirmed several expected patterns (Fig. 3), including a cluster of several probes in the SNRPN/SNURF locus which show hypermethylation in PWS samples and hypomethylation in the AS samples relative to the normal samples [21, 22], a cluster including several probes related to the FMR1 promoter locus which are hypermethylated in FXS male samples relative to the normal samples [23], and a cluster of several probes from the KCNQ10T1 locus which showed hypomethylation in the BWS samples relative to the normal samples [15, 24, 25].