GPX4 and cancer: Ferroptosis, a new form of PCD [20], characterized by hazardous lipid peroxidation and mitochondrial dysfunction [21], had been proved closely related to inhibition of cancer cells proliferation, migration, and invasion [22] Studies have shown that ferroptosis can affect the efficacy of cancer treatment and reverse the resistance to chemotherapy, targeted therapy, and immunotherapy by regulating GPX4 signaling pathways, iron metabolism, and lipid metabolism [16, 23, 24].