Except that, the results of KEGG enrichment analysis displayed that oridonin was associated with EGFR tyrosine kinase inhibitor resistance, platinum drug resistance, T cell receptor signaling pathway and (anti-programmed cell death 1) PD-L1 expression and (programmed death-ligand 1) PD-1 checkpoint pathway in cancer and other cancer chemotherapy-related pathways in OS cells, which suggested that oridonin might be involved in the drug resistance of OS. The gene discussed is PDCD1; the disease is cancer.