Within the last decade, clinical implications of this type-O associated VWF deficiency have been illuminated: BG O as a determinate for lower VWF levels has been found to be protective against venous and arterial thrombotic and thrombembolic events such as myocardial infarction, deep vein thrombosis, cerebral ischemia and peripheral vascular disease [9–13]. This evidence concerns the gene VWF and hyperinsulinemic hypoglycemia, familial, 4.