CD8A and cerebral malaria: In vivo imaging in both a mouse model of cerebral malaria and in mice expressing ovalbumin as a model antigen in oligodendrocytes showed a significant reduction in the crawling speed of CD8 T cells in CNS microvessels when endothelial MHC class I and the cognate CD8 T-cell antigen were present, supporting the notion that brain endothelial MHC class I-dependent cross-presentation of luminal and CNS-derived antigen reduced motility of CD8 T cells in CNS microvessels in vivo [3, 28].