Alzheimer's disease (AD), the most common among NDDs, is characterized by brain accumulation of extracellular Aβ aggregates known as plaques and intraneuronal Tau deposits called neurofibrillary tangles, that are also found in several other NDDs, including frontotemporal dementia, Pick's disease, corticobasal degeneration, progressive supranuclear palsy, argyrophilic grain disease as well as chronic traumatic encephalopathy, a condition where neuronal loss results from repetitive blast or concussive injuries [125]. The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.