Although the area affected by different proteinopathies, as well as the sites of neurodegeneration, can markedly vary among NDDs, TBI and stroke, it is worth considering that the coexistence of Aβ, Tau, and α-syn pathologies has been frequently observed in these conditions, including the LB variant of AD or the recurrent presence of tauopathy in PD and LB dementia. The gene discussed is MAPT; the disease is stroke disorder.