Interestingly, the Danish mutant BRI2 protein in FDD-KI rodents is unstable and undergo rapid degradation (Tamayev et al, 2010b; Yin et al, 2021a, b), mirroring the significant reduction in mature BRI2 levels, which is the functional form of BRI2, observed in brain lysates from FDD patients (Matsuda et al, 2011b; Tamayev et al, 2012a, 2010a, b). Here, ITM2B is linked to ADan amyloidosis.