Although the functional consequences of TREM2 processing are not well understood, TREM2 cleavage has been suggested to play a role in regulating the activity of microglia in the brain as well as in AD pathogenesis (Heslegrave et al, 2016; Lichtenthaler et al, 2022; Piccio et al, 2016; Suárez-Calvet et al, 2019). This evidence concerns the gene TREM2 and Alzheimer disease.