Importantly, it should be noted that mature BRI2, which represents the functional form of BRI2, exhibits reduced levels in the CNS of both FDD-KI rodents (Tamayev et al, 2010b; Yin et al, 2021a, b) and FDD patients (Matsuda et al, 2011b; Tamayev et al, 2010a, b). Here, ITM2B is linked to ADan amyloidosis.