The most significant effects (top hits) in CL2 included ENPP4 (which promotes haemostasis); ALOX15 (which generates bioactive lipid mediators including eicosanoids); GLIPR2 (which enhances type-I IFNs); MPPED2 (a metallophosphoesterase active in infection); INSR (insulin receptor); and MIR223 (an inhibitor of neutrophil extracellular trap (NET) formation in infection) (Supplementary Data 6). Here, MPPE1 is linked to infection.