In addition, the effects on metabolic-inflammatory parameters will be investigated and, namely, on glycemia, insulinemia, blood levels of inflammatory markers (CRP, TNF-α, IL-1, IL-6), oxidoreductive (malondialdehyde-MDA, TAC) and hormonal (androstenedione, dehydroepiandrosterone sulphate-DHEA-S), both in overweight and obese girls with PCOS and those with normal weight. This evidence concerns the gene TNF and polycystic ovary syndrome.