Aqueous humor TGFβ2 levels were a mean of 2.7-fold higher (p = 0.00005) in POAG (2297.1 ± 248.8 pg/ml; n = 15) compared with normal control eyes (860.6 ± 115.5 pg/ml). This evidence concerns the gene TGFB2 and open-angle glaucoma.