For example, open angle glaucoma presentations are associated with mutations of fibrillin-1, ADAMTS10 (a disintegrin and metalloproteinase with thrombospondin motifs-10) and LTBP2 (latent transforming growth factor β binding protein-2) that are different proteins involved in regulating microfibrils20,45–48. This evidence concerns the gene LTBP2 and open-angle glaucoma.