For example, a recent study has described the co-option of WNT4 under the control of ESR1 in the invasive lobular breast carcinoma, with downstream positive effects on tumor cell proliferation, mTOR signaling and mitochondrial function11,66 – the effects we do not observe in the transgenic mouse uterus, which may be due to the absence of cancer cells. Here, ESR1 is linked to invasive lobular breast carcinoma.