Moreover, Chi-square test identified tumor stage, HPV type, and tumor size were positively correlated with SPP1 expression, while tumor size and numbers of positive nodes were related to CD44 expression in CC patients from The Cancer Genome Atlas cervical squamous cell carcinoma (TCGA-CESC) (Fig. 9C, D and Table S4). Here, SPP1 is linked to cervical squamous cell carcinoma.