Unlike the Osx1-GFP::Cre line (Jakson lab #006361), which exhibited malocclusion and mild skeletal defects at a young age [27, 28], the Biocytogen Osx-Cre mice did not develop dental abnormalities and had comparable bone volume to Kdm7afx/fx mice (Fig. S1A–K). This evidence concerns the gene SP7 and Dental malocclusion.