TLR7 and obesity due to melanocortin 4 receptor deficiency: Consistent with endogenous activation of TLR7 occurring and playing a role in the development of MetS, TLR7 and TLR7/8 knockout mice were reported to have improved glucose tolerance tests, insulin tolerance tests, and reduced fat pad mass compared to wild‐type mice in the setting of diet‐induced obesity (Hanna Kazazian et al., 2019; Revelo et al., 2016).