We did not detect any significant synergistic effects of a 42% kcal from fat HFD on the development of splenomegaly or autoantibodies in response to the TLR7 agonist in FVB/N mice in this 12‐week study, or in our previous 6‐week study of IMQ treatment of C57BL/6J mice (Kakalij et al., 2022). Here, TLR7 is linked to Splenomegaly.