L3mbtl3 is mutated in medulloblastoma and is further implicated in other pathological disorders such as multiple sclerosis, insulin resistance, prostate cancer, and breast cancer (Andlauer et al., 2016; Bonasio et al., 2010; Kar et al., 2016; Lotta et al., 2017; Northcott et al., 2009). Here, L3MBTL3 is linked to multiple sclerosis.