EZH2 and cancer: The methylated K20 is recognized by specific methyl lysine reader L3MBTL3 to promote EZH2 for ubiquitin-dependent proteolysis by the CRL4DCAF5 ubiquitin E3 ligase complex, resulting in the disassembly of the PRC2 complex and reduction of H3K27 trimethylation in animals, MEFs, and cancer cells.