APOE and early-onset autosomal dominant Alzheimer disease: While suitable datasets were few, we found that an analysis of different APOE alleles (human nomenclature to denote the use of humanised alleles) in mice showed CC-DEGs for 3-month-old cerebral cortices homozygous for the Alzheimer’s disease-protective ε2 allele (APOE2) compared to cortices homozygous for the neutral-risk ε3 allele (APOE3, [23], Fig 2B).