CTTN and Sepsis: In addition, MYLK-coding SNPs are overrepresented in Blacks (46, 108), conferring increased risk and severity of sepsis/trauma-induced ARDS.A coding SNP in CTTN (47),the gene encoding cortactin, is similarly significantly overrepresented in Blacks with ARDS and increases the severity of sepsis, sickle cell disease, and ARDS (47).