In addition, MYLK-coding SNPs are overrepresented in Blacks (46, 108), conferring increased risk and severity of sepsis/trauma-induced ARDS.A coding SNP in CTTN (47),the gene encoding cortactin, is similarly significantly overrepresented in Blacks with ARDS and increases the severity of sepsis, sickle cell disease, and ARDS (47). This evidence concerns the gene CTTN and acute respiratory distress syndrome.