In addition, MYLK-coding SNPs are overrepresented in Blacks (46, 108), conferring increased risk and severity of sepsis/trauma-induced ARDS.A coding SNP in CTTN (47),the gene encoding cortactin, is similarly significantly overrepresented in Blacks with ARDS and increases the severity of sepsis, sickle cell disease, and ARDS (47). Here, CTTN is linked to sickle cell disease.