YTHDC2, which binds to the mRNA of the lipogenic genes SREBP1c, fatty acid synthase, SCD1, and acetyl-CoA carboxylase 1 (ACC1) and thus decreases the stability and expression of these genes, has recently been shown by Zhou et al.7 to be strikingly downregulated in the livers of obese mice and NAFLD patients. Here, ACACA is linked to metabolic dysfunction-associated steatotic liver disease.