These enzymes include methyltransferase like-3 (METTL3), METTL5, METTL14, METTL16, WT1-associated protein (WTAP), Vir-like m6A methyltransferase associated (also known as KIAA1429), RNA binding motif protein 15/15B (RBM15/15B), zinc finger CCCH-type containing 13 (ZC3H13), and HAKAI (also known as CBLL1, a RING-finger type E3 ubiquitin ligase).45,53–56 Among these m6A methyltransferases, METTL3 and METTL14 had the most pronounced effect on NAFLD. The gene discussed is METTL3; the disease is metabolic dysfunction-associated steatotic liver disease.