RUBCN and metabolic dysfunction-associated steatotic liver disease: For instance, Inhibiting autophagic flux and aggravating lipid droplet buildup in NAFLD are caused by METTL3-mediated m6A alteration, which is dependent on YTHDF1 increasing Rubicon mRNA stability.58 Collectively, the involvement of m6A regulators in NAFLD has shown complexity and diversity (Table 1), therefore, more research is needed to completely understand their functional mechanisms and clinical significance in NAFLD.