T2D is associated with the presence of some pathological features of Alzheimer disease (AD) and other dementias, including vascular damage and associated pathways6; overaccumulation of amyloid-β and tau phosphorylation7,8,9; and chronic neuroinflammation, insulin resistance, and blood-brain barrier damage that result from hyperglycemia and hyperinsulinemia.7,10,11. The gene discussed is MAPT; the disease is Alzheimer disease.