No previous study has investigated sclerostin concentrations after treatment with DR-HC, but in endogenous hypercortisolism, studies have found an inverse association between sclerostin levels and the level of cortisol excess and suggested that the findings were caused by an inhibition of glucocorticoids on osteocyte function and/or number [44, 45]. Here, SOST is linked to adrenal gland hyperfunction.