A database review of spontaneous adverse event reports for selected oral anti-VEGF drugs (all multikinase inhibitors) yielded an incidence of 19 cases of optic disc edema or ischemic optic neuropathy out of 691 total ocular adverse events for patients taking sunitinib, 3 out of 278 ocular adverse events for those taking pazopanib and none for those taking sorafenib [75]. This evidence concerns the gene VEGFA and anterior ischemic optic neuropathy.