In ITGB2- silenced ovarian cancer cells (A2780), the protein levels of PI3K (pi-PI3K), AKT (pi-AKT) and mTOR (pi-mTOR) decreased significantly, and the overexpression of PI3K and AKT reversed this change (Figure 3C–3F). This evidence concerns the gene ITGB2 and ovarian carcinoma.