What’s more, EM combined with DDP may promote the accumulation of intracellular divalent iron ions by inducing the downregulation of the expression of GPX4 and FTH1, resulting in the overaccumulation of intracellular ROS and LPO levels, and ultimately inducing Ferroptosis in MKN45/DDP cells, which in turn overcomes cisplatin resistance in gastric cancer. The gene discussed is GPX4; the disease is gastric cancer.