In addition, NF-κB is mainly composed of nuclear transcription factors p65 and p50 as homo-/heterodimers, which can coordinate a variety of gene expressions and influence biological functions such as cell differentiation, apoptosis, and tumor growth in vivo, with phosphorylation of p65 being one of the most critical modifications of NF-κB [16–18]. The gene discussed is NFKB1; the disease is neoplasm.