In summary, we initially clarified the mechanism of EM combined with DDP to overcome cisplatin resistance in gastric cancer, which may be that the combination of the two drugs inhibited the migration and invasion ability of drug-resistant cells, promoted apoptosis of drug-resistant cells, and down-regulated the expression of drug resistance-related proteins and genes through the NF-κB/Snail signaling pathway, thus inhibiting the proliferation of drug-resistant cells in gastric cancer. The gene discussed is NFKB1; the disease is gastric cancer.