The above results indicated that EM combined with DDP could inhibit the EMT process and further increase the sensitivity of gastric cancer-resistant cells to cisplatin by mediating the NF-κB/Snail signaling pathway to different degrees, which led to the downregulation of p-p65 and Snail expression and the upregulation of E-cadherin, thus improving the sensitivity of gastric cancer-resistant cells to cisplatin. This evidence concerns the gene SNAI1 and gastric cancer.