Our experimental results showed that p-p65 and Snail proteins were highly expressed and E-cadherin protein was lowly expressed after cisplatin resistance in gastric cancer, and after EM combined with DDP, the expressions of p-p65 and Snail were downregulated to different degrees, and the expression of E-cadherin was upregulated to different degrees. This evidence concerns the gene SNAI1 and gastric cancer.