HSA is an excellent conjugationpartner because it offers both serum half-life extension (t1/2 albumin ≈ 19 days) and is recycledthrough the FcRn.10 For instance, the useof albumin for half-life extension has been demonstrated with theapprovals of Eperzan, an albumin–GLP-1 fusion for the treatmentof type 2 diabetes mellitus in adults,11,12 and IDELVION,an albumin-factor IX fusion for the treatment and prophylaxis of bleedingevents and perioperative management.13 This evidence concerns the gene ALB and type 2 diabetes mellitus.