CDKN2A and diabetic kidney disease: In earlier investigations, ALOX12 in DKD found that the activation of the 12-LOX and p38 MAPK pathways in podocytes is involved in the development of DKD by mediating extracellular matrix (ECM) synthesis and conversion [30], and that 12-LOX mediates the upregulation of p16ink4a in MCs and glomeruli triggered by HG conditions [31].