Previous studies have shown that hyaluronic acid can inhibit the TGF-β-induced synovial fibrosis in a mouse model of arthritis by downregulating COL10A1 expression [30] and treatment with mignonette element-7 or glucuronic acid glycosides significantly reduces myocardial injury and fibrosis in a mouse model of myocardial fibrosis induced by isopropyl adrenaline by downregulating COL10A1 and fibrogenic factor gene expression [31]. This evidence concerns the gene COL10A1 and Myocardial fibrosis.