A bioinformatic multi-layer interference approach of context-dependent gene networks revealed that KIF2C was a target gene for ER−/HER2− (estrogen/human epidermal growth factor receptor 2) breast cancers and its gene expression was positively regulated by E2F1 (E2F transcription factor 1), which has crucial roles in cell cycle control [124,125]. The gene discussed is E2F1; the disease is breast carcinoma.