LPIN1 and lupus nephritis: On the other hand, females tend to be more affected by childhood-onset lupus nephritis [15]. Consanguinity is also revealed by demographic research, especially in RTD [14] and rhabdomyolysis related to LPIN1(Phosphatidate phosphatase-1 (lipin-1) efficiency [18], which may indicate a genetic susceptibility and a higher incidence in certain regions or groups.