Patients with persistently high levels of fetal globin typically exhibit less severe anemia, and milder clinical syndromes, and often do not require blood transfusions [19]. While many studies elucidate the role of elevated HbA2 in beta-thalassemia trait (βTT), less literature is available on addressing the role of HbA2 in disease severity in TDT [20-22]. This evidence concerns the gene HBA2 and beta thalassemia.