SHBG and hyperlipidemia: Specifically, it should be explained to any youth contemplating engaging in the use of PEDs that androgen production is vital to the development of secondary sexual characteristics in both males and females. Moreover, the healthcare provider responsible for overseeing an individual engaging in PED use should possess the knowledge to explain all pertinent risks, as well as feel prepared to suggest and encourage pertinent laboratory testing for comorbid pathologies such as hyperlipidemia, sex hormone binding globulin suppression, and hepatotoxicity.