We further demonstrated that activation of AHR signaling by delivery of AHR ligands induces epithelial barrier genes and attenuates IL-13–mediated induction of key AD signature genes, including CCL26. Aiming to elucidate the mechanism by which AHR attenuates the IL-13 response, we hypothesized that AHR interacts with and restrains STAT6. Here, CCL26 is linked to Alzheimer disease.