AHR and Alzheimer disease: Notably, the crosstalk between AHR and IL-13 does not appear to be limited to just skin barrier function; we compared in vitro AD-like conditions with and without AHR activation and demonstrated that the shared DEGs included not only skin barrier function (extracellular matrix, external structure), but also inflammatory processes, such as chemotaxis, humoral response, alternative complement, and IL-17 signaling (Figure 4C).