Although a previous study reported that oxidized low‐density lipoprotein (ox‐LDL) enhanced protective autophagy through the SOCE‐CaMKII‐mammalian target of rapamycin pathway in endothelial progenitor cells,22 the specific role of STIM1 in regulating autophagy in HCC cells has not been clarified. Here, STIM1 is linked to hepatocellular carcinoma.