Overall, 152 genes including HCLS1, EHF, PMEPA1, PPAP2B, FABP6, and GPAT3 showed obvious upregulation; 95 genes (such as IAH1, S100A4, HDGF, CYB5B, GNE, and KITLG) exhibited significant downregulation in CRC‐R cells (Figure 1A). This evidence concerns the gene CYB5B and colorectal carcinoma.