In addition, human HSD17B13 has been identified as a retinol dehydrogenase (RDH),206, 207 which catalyzes the conversion of retinol to retinaldehyde in combination with appropriate LD targeting and cofactors and is the rate‐limiting enzyme controlling the biosynthesis of trans‐retinoic acid during NAFLD progression.208. This evidence concerns the gene HSD17B13 and metabolic dysfunction-associated steatotic liver disease.